Zoo siab Crospovidone Excipient

Excipient yog dab tsi?

Ib qho excipient yog ib yam khoom tsim nrog rau cov khoom xyaw nquag ntawm cov tshuaj, suav nrog rau lub hom phiaj ntawm kev ruaj khov mus ntev, bulking li khoom formulations uas muaj cov khoom xyaw muaj zog hauv me me, los yog muab cov tshuaj kho kom zoo ntawm cov khoom xyaw hauv qhov kawg. daim ntawv ntau npaum li cas, xws li ua kom yooj yim rau kev nqus tshuaj, txo viscosity, los yog txhim kho solubility.

Khoom piav qhia:

Crospovidone European pharmacopeia monograph yog super decomposer nyob rau hauv ua npuas ncauj, uas disintegrates thiab degrades tso tawm active cov khoom xyaw nyob rau hauv cov ntsiav tshuaj, tsiav tshuaj, thiab tshuaj. ceev. Insoluble polyvinylpyrrolidone yog adsorbed ntawm swellable polymers nyob rau hauv pharmaceuticals thiab muaj ntau yam kev siv vim hais tias lawv muaj ib tug dispersing nyhuv, muaj peev xwm nqus tau ntau yam insoluble tshuaj, muaj peev xwm stabilize ntau yam suspending agents, thiab muaj peev xwm mus complex thiab tsim cov khoom. , Raws li kev nqus pa, thiab lwm yam, tuaj yeem ua cov tshuaj ntxiv.

CTFA lub npe:Crosslinked Polyvinylpyrrolidone

CSC No.:25249-54-1

EINECS:201-800-4

Molecular formula:(C6H9NO)n

Boiling Point:217.6 degree ntawm 760 mmHg

Melting point:300 degree

Qhov ntomQhov hnyav: 1.144g / cm3

Ntim:20kg / cardboard nruas

Cia:Khaws kom deb ntawm lub teeb, kaw, thiab khaws cia rau hauv qhov chaw tsaus.

Daim ntawv thov:

Polyvinylpyrrolidone crosslinking tuaj yeem siv rau hauv kev lag luam tshuaj, nws feem ntau yog siv los ua cov tshuaj disintegrant rau cov ntsiav tshuaj, tab sis kuj yog cov tshuaj thiab granules.Nws kuj tseem siv tau los ua cov tshuaj disintegrant thiab muab tub lim rau cov tshuaj ntsiav nyuaj.

Cov khoom no yog cov hmoov dawb los yog xim tsis muaj xim, tsis muaj ntxhiab tsw los yog me ntsis cov yam ntxwv tsw, yeej tsis muaj qab hau, insoluble hauv dej, alkali, acid thiab organic solvents. Nws muaj hygroscopicity thiab nqus dej. Nws dissolves thiab swells tom qab nqus dej, tab sis tsis tsim ib gel; Tom qab nqus dej, cov saw hlau molecular stretches thiab ntim tau nrawm, thiab qhov nthuav dav tuaj yeem ua rau cov ntsiav tshuaj tawg sai.

Cov khoom no muaj tib yam complexing zog li soluble povidone, thiab muaj peev xwm tsim complexes nrog cov tebchaw uas muaj hydroxyl, carbon thiab amino pawg, yog li hloov lub solubility, tsw, toxicity thiab lwm yam lub cev khoom ntawm lub compound.

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