Kev siv PVP hauv kev tshawb fawb thiab kev tsim kho tshuaj (1)
PVP tau dhau los ua cov khoom siv tshuaj polymer feem ntau siv hauv kev tshawb fawb thiab kev tsim kho tshuaj, thiab nws cov txiaj ntsig tau raug lees paub ntau thiab ntau dua, ua rau nws muaj ntau lub hom phiaj siv tshuaj. PVP yog cov dej-soluble polymer catalyzed los ntawm N-vinyl-2-pyrrolidone monomer. Nws yog ib qho yooj yim heev kom nqus noo noo thiab agglomerate. Nws yog yooj yim soluble nyob rau hauv polar organic solvents xws li dej thiab ethanol raws li ib tug ntawm nws daim ntawv thov yam ntxwv. Qhov hnyav molecular ntawm cov tshuaj povidone yog nyob nruab nrab ntawm 10,000 thiab 700,000. Nws yog feem ntau qhia los ntawm qhov loj ntawm K. Qhov loj ntawm K, qhov siab dua qhov hnyav molecular yog raws li qhia hauv cov lus hauv qab no. PVP muaj ntau yam khoom zoo heev, thiab nws daim ntawv thov hauv tshuaj tau dhau los ua ntau dua, nrog rau ntau thiab ntau daim ntawv thov. Cov ntsiab lus tseem ceeb ntawm nws daim ntawv thov hauv kev txhim kho thiab kev tshawb fawb ntawm kev npaj tshuaj hauv Suav teb tau sau tseg hauv qab no.
1. Binders rau qhov ncauj khoom npaj
PVP yog soluble hauv dej thiab qee qhov feem ntau siv cov kuab tshuaj organic, ua rau nws siv tau rau ntau qhov xwm txheej. Ua ntej tshaj plaws, rau cov neeg ua hauj lwm uas nkag siab txog cov cua sov thiab cov av noo, siv PVP ethanol tov raws li ib tug binder tuaj yeem tshem tawm cov yam ntxwv xws li dej thiab cua sov. Rau cov tshuaj hydrophobic, cov tshuaj aqueous tuaj yeem sib xyaw ua ke, thiab cov khoom siv tshuaj tuaj yeem yog hydrophilic. Nws yog qhov pab tau kom muaj kev sib cais ntawm cov tshuaj. Tsis tas li ntawd, PVP tuaj yeem muab ntxiv ua cov hmoov qhuav ua cov ntawv khi. Nws tuaj yeem txhim kho qhov tshwm sim ntawm qhov tshwm sim ntawm cov tshuaj hydrophobic thaum nws ntub dej nrog cov kuab tshuaj tsim nyog rau granulation los yog ua ib daim ntawv qhuav rau compression ncaj qha. Feem ntau siv K30 thiab K25, qhov ntau npaum ntawm PVPK30 feem ntau yog 2% -5%. Hauv kev siv tus neeg sawv cev effervescent, PVP yog cov nplaum zoo tagnrho, vim tias tus neeg sawv cev effervescent yuav tsum muaj kev tswj xyuas nruj ntawm cov dej noo, siv PVP ethanol tov raws li cov nplaum yuav daws tau qhov teeb meem no zoo. Lub resulting effervescent ntsiav tshuaj granules yog zoo nyob rau hauv disgust thiab yaj sai sai, thiab lawv muaj peev xwm ua npuas ncauj. Siv li ntawm 5% -10% PVP tov raws li ib tug binder kuj siv tau rau fluidized txaj spraying granulation. Cov kws tshwj xeeb sib xyaw diclofenac sodium nrog cov hmoov txhuv nplej siab, lactose, thiab lwm yam, nplawm thiab granulated nrog DQD ethanol tov kom tau txais cov granules ceev. Siv ib feem ntawm cov granules tam sim ntawd ua raws li ethylcellulose, ethanol, thiab acetone tov los coated cov sustained-tso granules. Cov saum toj no ob granules yog tov raws li 7K5 thiab ces encapsulated. Nws tseem tau tshaj tawm tias lub plab zom mov uas tau tso tawm-tso tshuaj ntsiav qhia cov tshuaj tso tawm tau zoo.
2.Siv rau thickening thiab thickening ntawm qhov ncauj kua npaj
PVP muaj keeb kwm ntev ua cov thickener hauv cov kua hauv qhov ncauj thiab muaj ntau yam kev siv. Piv txwv li, nws tuaj yeem siv los ua ib qho zoo thickening stabilizer nyob rau hauv emulsions thiab ncua kev kawm ntawv, PVPK-90, thiab cov polymer yog Adsorbed rau saum npoo ntawm ib tug colloidal ion los tsim ib tug nyias txheej ntawm molecules los tiv thaiv coalescence. Nyob rau hauv txoj kev tshawb no ntawm transdermal xa system ntawm dihydroetorphine los ntawm cov kws txawj, 50% ntawm PVP tau ntxiv thaum lub sijhawm npaj cov tsev qiv ntawv tshuaj. Cov txiaj ntsig tau ua pov thawj tias qhov piv ntawm PVP rau PVA thiab glycerin yog qhov tseem ceeb cuam tshuam rau kev ua haujlwm ntawm lub tsev qiv ntawv tshuaj. Ntxiv PVP tshuaj storehouse yog ib qho yooj yim kom qhuav thiab tawv. Levofloxacin tam sim no tau lees paub tias yog lub chaw kho mob ophthalmology nrog cov txiaj ntsig zoo. Cov kws tshaj lij tau tsim cov tshuaj levofloxacin qhov muag ua tshuaj tua kab mob rau lub hom phiaj no. Siv polyvinylpyrrolidone (PVP) ua ib lub thickener, npaj levofloxacin sustained-tso lub qhov muag tee sustained-tso formulation tuaj yeem tsim ib zaj duab xis nyias ntawm lub qhov muag tom qab instillation rau hauv lub qhov muag, tsis zoo li cov qhov muag zoo tib yam feem ntau ntawm cov kua tshuaj yuav poob. , kom cov tshuaj muaj peev xwm tswj tau lub sij hawm kho mob ntev nyob rau hauv lub qhov muag, thiab cov nyhuv curative yuav ntxiv dag zog rau; thiab cov tshuaj PVP muaj qee yam viscosity, fluidity tsawg, thiab zoo pob tshab, uas tsis cuam tshuam rau txoj kab ntawm qhov pom. Cov tshuaj pleev qhov muag oily yog qhov zoo dua. Nws tau raug tshaj tawm nyob rau hauv cov ntaub ntawv hais tias qhov sib ntxiv ntawm cellulose polymers tuaj yeem ncua lub sijhawm sib cuag ntawm cov tshuaj nrog lub qhov ntswg mucosa, yog li txhim kho cov nyhuv ntawm cov tshuaj. Yang Jianhong [5] et al. Hauv kev soj ntsuam kev tshawb fawb ntawm qhov ntswg mucociliary toxicity ntawm vitamin Bl2 nasal tee, ntxiv ntawm PVP ua cov thickener 1 % PVР tshuaj yeej tsis cuam tshuam rau kev txav ntawm cilia ntawm lub palate ntawm toads, thiab qhov txheeb ze inhibition feem pua ntawm cilia zog yog 90 %. %sab.