Kev siv PVP hauv kev tshawb fawb thiab kev tsim kho tshuaj (2)
3. Siv los ua cov khoom thauj khoom thauj khoom dispersion
Txhim kho qhov nqus ntawm cov tshuaj tsis zoo hauv lub cev ib txwm yog lub ntsiab lus kub. Yuav kom ua tiav lub hom phiaj no, xav txog kev nce nws cov solubility thiab solubility. Lub dispersion khoom yog disperse tsis zoo soluble tshuaj nyob rau hauv molecular, colloidal, microcrystalline, los yog amorphous lub xeev Nws yog tsim los ntawm ib tug dej-soluble cov ntaub ntawv, uas muaj peev xwm ho nce tus nqi dissolution thiab ua rau nws absorbed ntau. PVP yog cov khoom siv uas nquag siv rau cov nroj tsuag cov khoom tawg. Cov kws tshaj lij tau npaj carvedilol solid dispersions los ntawm kev sib piv cov kev tshawb fawb los txiav txim siab tias qhov kev sib cais ntawm carvedilol cov khoom dispersions nyob rau hauv ntau yam proportions thiab thawj cov hmoov ntawm cov tshuaj yog txawv heev (P< 0.05)="" los="" yog="" tseem="" ceeb="" heev="">< 0.001),="" qhov="" kev="" sib="" cais="" yog="" ntau="" dua="" li="" thawj="" cov="" hmoov="" ntawm="" cov="" tshuaj,="" thiab="" ob="" qho="" tib="" si="" dispersions="" ntawm="" car-peg-6000="" thiab="" car-pvp="" ob="" leeg="" qhia="" tib="" yam:="" raws="" li="" tus="" nqi="" ntawm="" cov="" cab="" kuj="" nce,="" qhov="" kev="" sib="" cais="" nrawm,="" tab="" sis="" raws="" li="" tus="" naj="" npawb="" ntawm="" cov="" cab="" kuj="" nce,="" qhov="" nce="" ntawm="" kev="" sib="" cais="" qeeb="" qeeb.="" cov="" nyhuv="" dissolution="" ntawm="" pvp="" raws="" li="" tus="" neeg="" nqa="" khoom="" ntawm="" carvedilol="" yog="" zoo="" dua="" li="" ntawm="" peg-6000.="" hauv="" lwm="" qhov="" kev="" kuaj="" kev="" laus,="" car-peg-6000="" yog="" qhov="" yooj="" yim="" rau="" hnub="" nyoog="" dua="" li="" car-pvp.="" yog="" li="" ntawd,="" tus="" sau="" ntseeg="" tias="" pvp="" yog="" siv="" los="" ua="" cov="" khoom="" tawg="" ntawm="" carvedilol.="" tus="" cab="" kuj="" zoo="" dua.="" ob="" qho="" tib="" si="" peg-6000="" thiab="" pvp="" feem="" ntau="" yog="" siv="" cov="" khoom="" sib="" cais,="" uas="" yog="" qhov="" yooj="" yim="" tsis="" cuam="" tshuam="" nrog="" kev="" txiav="" txim="" siab="" ntawm="" cov="" tshuaj="" tseem="" ceeb.="" tom="" qab="" carvedilol="" raug="" kho="" los="" ntawm="" kev="" siv="" tshuab="" dispersion,="" nws="" tuaj="" yeem="" ua="" rau="" muaj="" qhov="" sib="" txawv="" hauv="" vitro,="" yog="" li="" ua="" kom="" cov="" bioavailability="" hauv="" vivo,="" muab="" txoj="" hauv="" kev="" zoo="" rau="" carvedilol="" los="" ua="" kev="" npaj="" ua="" haujlwm="">
4. Siv los ua Pu membrane txheej khoom
Feem ntau, PVP nrog cov lus qhia tshwj xeeb tuaj yeem siv los ua cov khoom siv tshuaj yeeb yaj kiab los yog ua ke nrog lwm cov ntaub ntawv zaj duab xis vim nws qhov zoo tshaj plaws hloov tau. Kev xyaum tau ua pov thawj tias PVP tuaj yeem siv rau hauv cov txheej txheem txheej txheem ntawm cov dej thiab cov organic hnyav. Nws qhov zoo ntawm txheej txheej yog: nws tuaj yeem txhim kho qhov adhesion ntawm zaj duab xis rau saum npoo, txhim kho qhov sib txawv ntawm cov pas dej lossis cov dyes, thiab tuaj yeem siv los ua cov yeeb yaj kiab plasticizer. Nws tuaj yeem hloov lub sijhawm tawg ntawm zaj duab xis raws li cov khoom siv hydrophobic. Cov concentration ib txwm rau txheej yog 0.5% --- 5%. Tam sim no, muaj PVP / VA series cov khoom siv tshwj xeeb los ua cov ntaub ntawv ua yeeb yaj kiab. Lawv yog copolymer ntawm VP (vinyl pyrrolidone) thiab VA (vinyl acetate).