Kev siv PVP hauv kev tshawb fawb thiab kev tsim kho tshuaj (3)
Lub solubility ntawm rosiglitazone maleate nyob rau hauv cov hnyuv yog me me. Nws tau kwv yees tias nws qhov nqus nqus hauv cov hnyuv yuav cuam tshuam los ntawm qhov no. Yog li ntawd, nws yog ib qho tsim nyog yuav tau ua kom rosiglitazone maleate rau hauv cov khoom tawg kom nce nws cov solubility. Thiab dissolution tus nqi. Infrared spectroscopy tsom xam ua pov thawj tias tsis muaj tshuaj lom neeg cov tshuaj tiv thaiv ntawm ob, thiab X-ray hmoov diffraction tsom xam qhia tias nws tau tawg nyob rau hauv cov cab kuj PVPK30 nyob rau hauv lub xeev amorphous. Siv cov ntaub ntawv dej-soluble raws li tus neeg nqa khoom tuaj yeem txhim kho cov kev sib cais thiab kev nqus ntawm cov tshuaj los ntawm kev txhim kho cov wettability ntawm cov tshuaj, kom ntseeg tau tias cov tshuaj dispersibility siab thiab cov khoom siv lead ua inhibitory ntawm cov khoom nqa khoom. Tus sau tau npaj cov khoom sib cais ntawm 1:5, 1:10, 1:15, thiab 1:20 (tshuaj: PVPK30), raws li. Tsis muaj qhov sib txawv tseem ceeb hauv qhov kev sib cais. Raws li tus naj npawb ntawm excipients, ib qho khoom tawg ntawm 1: 5 raug xaiv.
5. Siv nyob rau hauv sustained thiab tswj kev tso tawm npaj
PVP tuaj yeem siv los ua cov nplaum, retarders, penetration enhancers, thiab lwm yam. Cov kws tshaj lij tau tsim ib txheej ib txheej nifedipine qhov ncauj osmotic twj tso kua mis ntsiav tshuaj, optimized formulation thiab kev npaj tsis ntawm nifedipine qhov ncauj osmotic twj tso kua mis ntsiav tshuaj, thiab txiav txim siab lub optimum ntsiav tshuaj formulation, nyob rau hauv uas PVP yog 7.08% raws li kev nkag mus.
6. PVP-I (povidone-iodine npaj)
PVP-I (Povidone-iodine npaj) yog ib qho kev sib xyaw ua ke tsim los ntawm iodine thiab PVP. Nws yog ib qho zoo heev thiab spectral tshiab fungicide. Piv nrog iodine, nws muaj qhov tsis muaj zog, dej solubility zoo, thiab yuav luag tsis muaj qhov khaus. Kev ua xua thiab lwm yam zoo. Tam sim no, ntau yam khoom tau raug tshawb fawb los yog twb muaj nyob rau hauv kev ua lag luam, suav nrog ntau hom kev daws teeb meem (cov tshuaj tua kab mob ntawm daim tawv nqaij thiab cov tshuaj tua kab mob ophthalmic), suppositories (qhov chaw mos suppositories, urethral suppositories, thiab effervescent suppositories), tshuaj pleev, thiab pleev xim.